Resumen Introducción: existe una amplia variedad de fórmulas o preparados de nutrición enteral y fórmulas o preparados infantiles. La consulta de información relacionada debe hacerse en las herramientas propias de cada laboratorio, lo que dificulta la visión crítica y la comparativa entre las mismas. Objetivo: describir el desarrollo de NEmecum como la primera web que permite realizar una búsqueda dirigida e independiente de fórmulas de nutrición o preparados infantiles, analizar el abanico nutricional actual en España y evaluar los datos de uso de la herramienta. Métodos: se desarrolló la estructura de una base de datos que unifica los parámetros de todas las fórmulas y se analizó el abanico nutricional español. Posteriormente, se seleccionaron los principales algoritmos de búsqueda dirigida y se codificó la herramienta digital. Se llevó a cabo una intensa difusión y se evaluó el impacto obtenido. Se analizaron el perfil de usuarios y centros registrados y los datos de uso de la herramienta y se evaluó su usabilidad mediante el cuestionario System Usability Scale (SUS). Resultados: se obtuvo una web responsive de acceso gratuito (http://nemecum.com) que permite realizar búsquedas dirigidas en base a unos filtros de búsqueda preestablecidos. La herramienta permitió analizar detalladamente el abanico nutricional en España, observándose la gran variedad de fórmulas disponibles de similares características. La campaña de difusión consiguió incrementar su uso de forma exponencial y cuenta actualmente con 1.370 usuarios y 79 centros registrados. La usabilidad fue valorada como excelente. Conclusión: el desarrollo de NEmecum supone una herramienta valiosa en la búsqueda y consulta de datos de fórmulas o preparados de nutrición enteral y fórmulas o preparados infantiles.

Abstract Introduction: there is a wide variety of enteral nutrition and infant formulas preparations. When there is a need to find infomation on a product, only the infomation from industy is available. Comparison amomg products becomes then ardous. Objective: to describe the development of NEmecum as the first website that allows a directed and independent search for enteral nutrition products and infant formulas, currently available in Spain, and to evaluate the initial use of NEmecum. Methods: the structure of a database that unifies the parameters of all formulas was developed, and the nutritional composition of all formulas was analyzed. Subsequently, the main search algorithms were selected and the digital tool was codified. Intensive dissemination was performed and the impact was evaluated. The profile of users and registered centers and the use of the tool were analyzed, and its usability was evaluated using the System Usability Scale (SUS) questionnaire. Results: a free-access responsive website (http://nemecum.com) that allows searches based on pre-established search filters was obtained. This tool allows for a detailed analysis available formulas in Spain by observing a wide variety of formulas with similar characteristics. The dissemination campaign managed to increase its use exponentially, currently reaching 1,370 users and 79 registered centers. Usability was rated as excellent. Conclusion: the development of the NEmecum represents a valuable tool in the search and consultation of the characteristics of enteral nutrition formulas and infant preparations.

Abstract New methods of early detection and risk assessment have been studied aiming to predict the prognosis of patients and directing a specialized treatment of the oral tongue squamous cell carcinoma (OTSCC). In this context, several molecular biomarkers have been investigated for this purpose, and, among them, the heat shock protein 27 (HSP27) can be named. The study aimed to analyze whether heat shock protein 27 (HSP27) exerts any influence on OTSCC, correlating its immunoexpression with clinicopathological parameters, and patient survival. The sample comprised 55 OTSCC cases and 20 normal oral mucosa specimens. The malignancy grading systems proposed by the WHO in 2005, Brandwein-Gensler et al., and Almangush et al. were applied in a histomorphological study. HSP27 expressions were evaluated through the Immunoreactivity Score System (IRS). Significant values were considered at p <0.05 for all statistical tests. Higher IRS results were observed for normal oral mucosa specimens when compared to OTSCC cases (p <0.001). No significant associations between HSP27 immunostaining, the analyzed clinicopathological parameters and patient survival were observed. The results of the present study indicate lower HSP27 expression in OTSCC cases compared to normal oral mucosa specimens. Thus, HSP27 expression does not seem to influence patient prognosis.

Resumo Novos métodos de detecção precoce e avaliação de risco estão sendo estudados com o intuito de predizer o prognóstico dos pacientes e direcionar um tratamento diferenciado. Neste contexto, vários biomarcadores moleculares têm sido investigados com esta finalidade, dentre eles a heat shock protein 27 (HSP27). Esta pesquisa objetivou analisar se a HSP27 exerce alguma influência nos carcinomas de células escamosas de língua oral (CCELO), correlacionando a sua imunoexpressão com parâmetros clinicopatológicos e com a sobrevida dos pacientes. A amostra foi constituída por 55 casos de CCELO e 20 espécimes de mucosa oral normal. Os sistemas de gradação de malignidade propostos pela OMS em 2005, Brandwein-Gensler et al. e Almangush et al. foram aplicados em um estudo histomorfológico. A expressão da HSP27 foi avaliada através do Sistema de Escore de Imunorreatividade (IRS). Para todos os testes estatísticos foram considerados valores significativos com p<0,05. Foi observado um maior IRS para a mucosa oral normal quando comparado aos casos de CCELO (p<0,001). Não foram encontradas associações significativas entre a imunomarcação da HSP27 com os parâmetros clinicopatológicos analisados e com a sobrevida dos pacientes. Os resultados do presente estudo indicam uma menor expressão da HSP27 nos casos de CCELO quando comparados aos espécimes de mucosa oral normal. Assim, a expressão da HSP27 parece não influenciar o prognóstico dos pacientes.

This article describes a proposed framework called Telehealth Service Maturity Model (TMSMM.br) for evaluating the current stage of telehealth centers in the Brazilian context. The steps included literature review, compilation and interpretation, data collection instrument, survey with center coordinators, model development, and evaluation process. The review resulted in 857 quality aspects for telehealth services, grouped into 12 themes with 34 topics. TMSMM.br consists of defining 3 foundational dimensions (themes, services, stages) and provides a standardized set of 200 requirements ordered across 5 thematic domains (structure, organization, user, operation and community) for 8 services (consultation, consultation, diagnosis, treatment and referral, education and training, social control and communication, healthcare network, and research, development, and innovation). TMSMM.br enables telehealth centers to identify and compare essential characteristics and their maturity stages.

Este artículo describe una propuesta de marco de referencia llamado Modelo de Madurez de Servicios de Telemedicina (TMSMM.br) para evaluar la etapa actual de los centros de telemedicina en el contexto brasileño. Las etapas incluyeron revisión de literatura, compilación e interpretación, instrumento de recolección, encuesta a coordinadores de centros, desarrollo del modelo y proceso de evaluación. La revisión resultó en 857 aspectos de calidad para servicios de telemedicina, agrupados en 12 temas con 34 tópicos. TMSMM.br consiste en la definición de 3 dimensiones estructurales (temas, servicios, etapas) y proporciona un conjunto estandarizado de 200 requisitos ordenados en 5 dominios temáticos (estructura, organización, usuario, operación y comunidad) para 8 servicios (consulta, asesoría, diagnóstico, tratamiento y remisión, educación y capacitación, control social y comunicación, red de atención de salud e investigación, desarrollo e innovación). TMSMM.br ayuda a los centros de telemedicina a identificar y comparar características esenciales y sus etapas de madurez

Este artigo descreve uma proposta de framework denominado Modelo de Maturidade de Serviços de Telessaúde (TMSMM.br) para avaliação do estágio corrente dos núcleos de telessaúde no contexto brasileiro. As etapas incluíram revisão da literatura, compilação e interpretação, instrumento de coleta, inquérito com coordenadores de núcleos, elaboração do modelo e do processo de avaliação. A revisão resultou 857 aspectos de qualidade para serviços de telessaúde, agrupados em 12 temas com 34 tópicos. TMSMM.br consiste na definição de 3 dimensões estruturantes (temas, serviços, estágios) e provê um conjunto padronizado de 200 requisitos ordenados em 5 domínios temáticos (estrutura, organização, usuário, operação e comunidade) para 8 serviços (consulta, consultoria, diagnóstico, tratamento e encaminhamento, formação e capacitação, controle social e comunicação, rede de atenção à saúde, e pesquisa, desenvolvimento e inovação). TMSMM.br colabora para que núcleos de telessaúde possam identificar e comparar características essenciais e seus estágios de maturidade.

Resumen La presente investigación hace un análisis con respecto al uso de métodos alternativos de solución de conflictos aplicados en las sucesiones testadas. En principio, hay una introducción con respecto al conflicto en la sucesión y como este puede surgir dentro de un testamento. Posteriormente, hay una descripción sobre los sujetos que intervendrán dentro del conflicto, los cuales no se limitan solo a las personas inmersas dentro de este. Después, se expone brevemente sobre el testamento y su contenido para luego puntualizar en todo lo concerniente a la cláusula testamentaria y cómo debe ser establecida en el testamento. Finalmente, el artículo presenta un análisis comparativo del uso de la mediación y el arbitraje en los conflictos sucesorios testamentarios en varios países para luego establecer la posibilidad de aplicarlos en Ecuador.

Abstract The present investigation makes an analysis on the use of alternative dispute resolution, applied in testated successions. In principle, it has an introduction regarding the conflict in inheritance and how it can arise within the will. Subsequently, there is a description of the subjects that will intervene in the conflict, which are not limited only to the people immersed in it. Afterwards, it is briefly explained about the will and its content to then point out everything related to the testamentary clause and how it should be established in the will. Finally, the article presents a comparative analysis of the use of mediation and arbitration in testamentary succession disputes in various countries, and then establishes the possibility of applying them in Ecuador.

Resumen: Objetivo: Describir las características clínicas y paraclínicas de pacientes con diagnóstico de sepsis atendidos durante 4 años en un hospital de alta complejidad. Pacientes y Método: estudio observational descriptivo de pacientes entre 1 mes y 17 años con diagnóstico de sepsis. Se recolectaron variables demográficas, clínicas, paraclínicas e intervenciones terapéuticas, determinando factores predictores de mortalidad. Estadígrafos: prueba de Chi cuadrado o Fisher. Resultados: Se incluyeron 186 pacientes, 72% con comorbilidades. Los focos de infección más frecuentes fueron pulmonares (29%), gastrointestinal (11%) y bacteriemia asociada a catéter (11%). El 60% presentó al menos una disfunción orgánica, siendo la más frecuente la respiratoria (70%). La disfunción orgánica múltiple (SDOM) se presentó en el 60%. La identificación de patógenos en los hemocultivos ocurrió en el 37% de los eventos. La detección adecuada de la sepsis ocurrió en el 48%. En la primera hora el 67% recibieron fluidos de reanimación y el 36% antibióticos. El 33% requirió soporte vasoactivo y 34% ventilación mecánica. La mortalidad fue del 12%, mayor en pacientes con alguna disfunción de órgano y con SDOM. Conclusiones: La disfunción orgánica fue frecuente, presentándose mayor mortalidad en pacientes con alguna disfunción orgánica y en pacientes con SDOM. A pesar de las iniciativas a nivel mundial e institucional enfocadas a mejorar el diagnóstico y tratamiento, la detección adecuada de la sepsis ocurrió en menos de la mitad de los pacientes, y la administración de fluidos y antibióticos fueron subóptimas.

Abstract: Objective: To describe the clinical and laboratory characteristics of patients with sepsis admitted to a high-complexity healthcare center in Latin America. Patients and Method: Descriptive observational study. Patients between one month to 17 years of age with sepsis diagnosis were included. Studied variables included demographics, clinical and laboratory characteristics, and treatment administered, determining predictors of mortality. A descriptive analysis was performed using the Chi-square or Fisher test. Results: 186 patients were included and 72% of them had comorbidities. Respiratory disease was the most frequent source of sepsis (29%), followed by gastrointestinal infection (11%) and catheter-related bacteremia (11%). 60% of patients had at least one organ dysfunction, the most frequent being respiratory dysfunction (70%). 60% of the patients presented multiple organ dysfunction syndrome (MODS). Blood cultures showed a positive result in 37% of cases. The two most common first-hour interventions included IV resuscitation fluids (67%) and antibiotics (36%). Vasopressor support and mechanical ventilation were used in 33% and 34% of patients, respectively. Overall mortality was 12% and was higher in patients diagnosed with MODS (59%) or who presented with some organ dysfunction. Conclusion: Organ dysfunction was frequent. Patients with some type of organ dysfunction or MODS presented higher mortality. Despite global and institutional guidelines focused on improving diagnosis and treatment, in less than half of the patients sepsis was adequately detected and first-hour IV fluids and antibiotics administration rates were below 70%.

Resumen: Objetivo: Describir las características clínicas y paraclínicas de pacientes con diagnóstico de sepsis atendidos durante 4 años en un hospital de alta complejidad. Pacientes y Método: estudio observational descriptivo de pacientes entre 1 mes y 17 años con diagnóstico de sepsis. Se recolectaron variables demográficas, clínicas, paraclínicas e intervenciones terapéuticas, determinando factores predictores de mortalidad. Estadígrafos: prueba de Chi cuadrado o Fisher. Resultados: Se incluyeron 186 pacientes, 72% con comorbilidades. Los focos de infección más frecuentes fueron pulmonares (29%), gastrointestinal (11%) y bacteriemia asociada a catéter (11%). El 60% presentó al menos una disfunción orgánica, siendo la más frecuente la respiratoria (70%). La disfunción orgánica múltiple (SDOM) se presentó en el 60%. La identificación de patógenos en los hemocultivos ocurrió en el 37% de los eventos. La detección adecuada de la sepsis ocurrió en el 48%. En la primera hora el 67% recibieron fluidos de reanimación y el 36% antibióticos. El 33% requirió soporte vasoactivo y 34% ventilación mecánica. La mortalidad fue del 12%, mayor en pacientes con alguna disfunción de órgano y con SDOM. Conclusiones: La disfunción orgánica fue frecuente, presentándose mayor mortalidad en pacientes con alguna disfunción orgánica y en pacientes con SDOM. A pesar de las iniciativas a nivel mundial e institucional enfocadas a mejorar el diagnóstico y tratamiento, la detección adecuada de la sepsis ocurrió en menos de la mitad de los pacientes, y la administración de fluidos y antibióticos fueron subóptimas.

Abstract: Objective: To describe the clinical and laboratory characteristics of patients with sepsis admitted to a high-complexity healthcare center in Latin America. Patients and Method: Descriptive observational study. Patients between one month to 17 years of age with sepsis diagnosis were included. Studied variables included demographics, clinical and laboratory characteristics, and treatment administered, determining predictors of mortality. A descriptive analysis was performed using the Chi-square or Fisher test. Results: 186 patients were included and 72% of them had comorbidities. Respiratory disease was the most frequent source of sepsis (29%), followed by gastrointestinal infection (11%) and catheter-related bacteremia (11%). 60% of patients had at least one organ dysfunction, the most frequent being respiratory dysfunction (70%). 60% of the patients presented multiple organ dysfunction syndrome (MODS). Blood cultures showed a positive result in 37% of cases. The two most common first-hour interventions included IV resuscitation fluids (67%) and antibiotics (36%). Vasopressor support and mechanical ventilation were used in 33% and 34% of patients, respectively. Overall mortality was 12% and was higher in patients diagnosed with MODS (59%) or who presented with some organ dysfunction. Conclusion: Organ dysfunction was frequent. Patients with some type of organ dysfunction or MODS presented higher mortality. Despite global and institutional guidelines focused on improving diagnosis and treatment, in less than half of the patients sepsis was adequately detected and first-hour IV fluids and antibiotics administration rates were below 70%.

ABSTRACT: Introduction: Hopelessness is characterized as the subject's negative outlook on the future. Individuals in deprivation of liberty are predisposed to suffering and loss of hope. Objective: To identify the prevalence, level of hopelessness and the correlation with depression and anxiety in women deprived of liberty. Materials and method: Quantitative and descriptive cross-sectional study, conducted in a Correctional Facility in Brazil, with 77 women by non-probability sampling. The data collection used were: a) Sociodemographic form; b) Beck Depression Inventory (BDI); c) Beck Anxiety Inventory (BAI); and d) Beck Hopelessness Inventory (BSH). Results: In the sample, 5.2% of the subjects presented hopelessness with moderate and severe levels. Higher mean scores of hopelessness were perceived in women who never studied (7.33), had no profession (5.04), no religion (7.14), and did not develop labor activities during incarceration (4.86). Higher mean scores of hopelessness were identified in women who had symptoms of depression (5.31) and anxiety (4.63). There was a positive correlation between the BHS and BDI scores. Conclusion: There was a low prevalence of hopelessness. It was associated with unfavorable socioeconomic conditions and the lack of work activities during the period of incarceration. Hopelessness correlated with depression, and people with anxiety symptoms had higher levels of hopelessness. It is suggested that hopelessness among people deprived of liberty be investigated in clinical practice and that work and educational activities be promoted during incarceration to promote hope and mental health.

RESUMEN: Introducción: La desesperanza se caracteriza como la perspectiva negativa del sujeto sobre el futuro. Las personas privadas de libertad están predispuestas al sufrimiento ya la pérdida de la esperanza. Objetivo: Identificar la prevalencia, el nivel de desesperanza y la correlación con depresión y ansiedad en mujeres privadas de libertad Materiales y método: Estudio transversal descriptivo cuantitativo realizado en un EsTablecimiento Penitenciario con 77 mujeres, muestreo no probabilístico. Se utilizaron para la recolección de datos: a) ficha sociodemográfica; b) Inventario de Depresión de Beck (BDI); c) Inventario de Ansiedad de Beck (BAI); yd) Inventario de Desesperanza de Beck (BSH) Resultados: En la muestra, el 5,2% de los sujetos entrevistados mostró desesperanza, con niveles moderados y severos. Se observaron mayores promedios de desesperanza en las mujeres que nunca estudiaron (7,33), no tenían profesión (5,04), no tenían religión (7,14) y no realizaron actividades laborales durante el período de encarcelamiento (4,86). Se identificaron mayores medias de desesperanza en mujeres que presentaban síntomas de depresión (5,31) y ansiedad (4,63). Hubo una correlación positiva entre las puntuaciones BHS y BDI. Conclusión: Hubo una baja prevalencia de desesperanza. Se asoció a condiciones socioeconómicas desfavorables y al no desarrollo de actividades laborales durante el período de encarcelamiento. La desesperanza se correlacionó con la depresión, y las personas con síntomas de ansiedad tenían niveles más altos de desesperanza. Se sugiere investigar la desesperanza entre las personas privadas de libertad en la práctica clínica y en la investigación, así como la promoción de actividades laborales y educativas durante el período de encarcelamiento para promover la esperanza y la salud mental.

RESUMO: Introdução: A desesperança é caracterizada como a perspectiva negativa do sujeito quanto ao futuro. Os indivíduos em privação de liberdade estão predispostos ao sofrimento e à perda de esperança. . Objetivo: Identificar a prevalência, o nível de desesperança e a correlação com a depressão e ansiedade em mulheres privadas de liberdade. Materiais e método Estudo quantitativo e descritivo com corte transversal, realizado em um Estabelecimento Prisional no Brasil, com 77 mulheres por amostragem não probabilística. Foram utilizados na coleta de dados: a) Formulário sociodemográfico; b) Inventário de Beck Depressão (BDI); c) Inventário de Beck Ansiedade (BAI); e d) Inventário de Beck Desesperança (BSH). Resultados: Na amostra, 5,2% dos sujeitos apresentaram desesperança com níveis moderado e grave. Maiores médias de desesperança foram percebidas em mulheres que nunca estudaram (7,33), desprovidas de profissão (5,04) bem como de religião (7,14) e que não desenvolviam atividades laborais no período do encarceramento (4,86). Maiores médias de desesperança foram identificas em mulheres que possuíam sintomas de depressão (5,31) e ansiedade (4,63). Houve correlação positiva entre o escore BHS e BDI. Conclusão: Houve baixa prevalência de desesperança. Ela esteve associada às condições socioeconômicas desfavoráveis e ao não desenvolvimento de atividades laborais no período de encarceramento. A desesperança se correlacionou à depressão, e as pessoas com sintomas de ansiedade apresentaram maiores níveis de desesperança. Sugere-se a investigação da desesperança entre as pessoas privadas de liberdade na prática clínica bem como a promoção de atividades laborais e educacionais no período de encarceramento para promover a esperança e a saúde mental

ABSTRACT Background: Complications of leprosy neuritis are considered serious and apparent, with the potential to disable and/or limit individuals. These complications affect not only a patient’s physical functioning, but also their family and social lives, while directly impacting the ability to work and/or maintain financial independence, subsequently interfering with their overall quality of life. The present review, therefore, aimed to analyze the effectiveness of neurolysis as an alternative treatment for the complications associated with leprosy neuritis. Methods: The present review was performed based on the Joanna Briggs Institute methodology, in an effort to answer the following research question: what is the effectiveness of neurolysis as a treatment for leprosy neuritis complications? This research question was defined using the patient-intervention-outcome (PIO) framework, where leprosy represents ‘P’, neurolysis for ‘I’, and neuropathic pain/motor function/sensorial function/physical disability/quality of life for ‘O’. Randomized and non-randomized clinical trials and prospective observational cohort studies were included in the present review, with no time or date restrictions. Results: The present review included 1 randomized clinical trial and 10 prospective studies, published between 1976 and 2020. All of the outcomes showed improvement, with relief from neuropathic pain being the primary finding. Conclusions: The evidence obtained in the present review suggested that neurolysis is an effective alternative for the treatment of physical disabilities, the recovery of sensory and motor function, the restoration of quality of life, and neuropathic pain relief.

ABSTRACT Introduction: With the advent of COVID-19, teledentistry and remote monitoring have become an imminent reality that allows orthodontists to monitor orthodontic treatment through virtual checkups, which complement in-office appointments. Objective: To evaluate the effectiveness of using teledentistry in monitoring the evolution of orthodontic treatment. Material and Methods: Searches were performed in on-line databases. PECO strategy focused on comparing orthodontic patients exposed and not exposed to teledentistry. Searches and data extraction followed PRISMA guidelines. The assessment of the risk of bias and the certainty of the evidence was performed using the ROBINS-I and GRADE tools, respectively. A meta-analysis was also performed. Results: Out of 1,178 records found, 4 met the criteria and were included in the qualitative analysis. The risk of bias for follow-up assesment in aligner treatment was low to moderate; while for interceptive treatment, it was high. Studies are favorable to the use of teledentistry. The meta-analysis was performed with aligners studies only, due to heterogeneity. The certainty of the evidence was considered very low. Conclusion: With very low certainty of evidence, teledentistry using Dental Monitoring® software is effective as an aid in monitoring the evolution of interceptive orthodontic treatment (high risk of bias) and, especially, treatment performed with aligners (low to moderate risk of bias). The meta-analysis evidenced a reduction in the number of face-to-face appointments (mean difference = −2.75[−3.95, -1.55]; I2=41%; p<0.00001) and the time for starting refinement (mean difference = −1.21[−2.35, -0.08]; I2=49%; p=0.04). Additional randomized studies evaluating corrective orthodontic treatment with brackets and wires are welcome.

RESUMO Introdução: Com o advento da COVID-19, a teleodontologia e o monitoramento remoto tornaram-se uma realidade iminente, permitindo ao ortodontista acompanhar o tratamento ortodôntico por meio de checkups virtuais, que complementam as consultas presenciais. Objetivo: Avaliar a eficácia do uso da teleodontologia no acompanhamento da evolução do tratamento ortodôntico. Material e Métodos: Buscas foram realizadas em bases de dados on-line. A estratégia PECO focou na comparação de pacientes ortodônticos expostos e não expostos à teleodontologia. As buscas e a extração dos dados seguiram a metodologia PRISMA. A avaliação do risco de viés e da certeza da evidência foi realizada com as ferramentas ROBINS-I e GRADE, respectivamente. Uma metanálise também foi realizada. Resultados: Dos 1.178 estudos encontrados, 4 atenderam aos critérios e foram incluídos na análise qualitativa. O risco de viés para a avaliação do acompanhamento de tratamentos com alinhadores foi baixo a moderado; enquanto para o tratamento interceptativo, foi alto. Os estudos são favoráveis ao uso da teleodontologia. A meta-análise foi realizada apenas com estudos de alinhadores, devido à heterogeneidade. A certeza da evidência foi considerada muito baixa. Conclusão: Com muito baixo nível de certeza da evidência, a teleodontologia utilizando o software Dental Monitoring® é eficaz para auxiliar no acompanhamento da evolução do tratamento ortodôntico interceptativo (alto risco de viés) e, principalmente, do tratamento realizado com alinhadores (risco de viés baixo a moderado). A metanálise evidenciou redução no número de atendimentos presenciais (diferença média = −2,75[−3,95, -1,55]; I2=41%; p<0,00001) e no tempo para início do refinamento (diferença média = −1,21[−2,35, -0,08]; I2=49%; p=0,04). Estudos randomizados adicionais avaliando o tratamento ortodôntico corretivo com braquetes e fios são bem-vindos.

ABSTRACT The degradation of urban rivers is a phenomenon caused by virtually all cities intersected by rivers. Currently, there is a substantial number of revitalization projects in progress. Nonetheless, their execution demands significant investments, particularly for water quality enhancement. Moreover, apart from the cost factor, the scarcity of space along their banks constrains the implementation of improvement systems. This study introduces a simplified methodology aimed at evaluating the technical feasibility of revitalization interventions within urban river segments, with a focus on enhancing water quality and user experience. The method follows a structured framework encompassing four sequential phases: execution of hydraulic, hydrological, and sanitary analyses concerning the watershed; development of foundational principles and intervention strategies pertaining to the riverbed; appraisal of the congruence between proposed interventions and the intrinsic attributes of the river channel; comprehensive assessment of the overall viability of the revitalization initiative. The method's validation was conducted through a case study involving the Dilúvio Stream in Porto Alegre, RS, showcasing its coherent application and adaptability within the predetermined premises. Thus, the methodology emerges as a preliminary decision-making support tool for projects related to the urban river requalification domain, facilitating the identification of met prerequisites and provision of informed guidance.

RESUMO A degradação dos rios urbanos é um fenômeno causado por praticamente todas as cidades com rios que as cruzam, e atualmente há um grande número de projetos de revitalização, no entanto a sua execução requer grandes investimentos, em especial, para melhoria da qualidade d´água. E além do custo a falta de espaço em suas margens limita a instalação de sistemas de melhoramento. Neste estudo, é proposto um método simplificado para avaliar a viabilidade técnica de intervenções de revitalização em trechos urbanos de rios, abordando melhorias na qualidade da água e na experiência de uso. O método é estruturado em etapas sequenciais: condução de análises hidráulicas, hidrológicas e sanitárias da bacia; formulação de premissas e estratégias de intervenção no leito do rio; avaliação da compatibilidade entre as propostas e as características da calha fluvial; avaliação global da viabilidade do projeto de revitalização. A validação do método foi realizada através de um estudo de caso no Arroio Dilúvio em Porto Alegre – RS, onde se evidenciou sua consistência e aplicabilidade em conformidade com as premissas estabelecidas. O método emerge como uma ferramenta de apoio à tomada de decisão preliminar em projetos de requalificação de rios urbanos, oferecendo a capacidade de identificar requisitos satisfeitos e direcionar escolhas informadas.

SUMMARY OBJECTIVE: This study aimed to assess the sociodemographic and clinical profile of women deprived of their liberty and to identify the prevalence of sexually transmitted diseases and human papillomavirus through self-sampling samples. METHODS: This is an epidemiological, cross-sectional, observational, and descriptive study of the prevalence and correlation of the diagnosis of human papillomavirus infection in 268 encarcered women in Amazonas submitted to self-sampling from June 2019 to September 2020 using the genotyping analysis. Patients with positive and inconclusive results were evaluated by commercialized PCR to detect pathogens causing sexually transmitted diseases. The sample size used was based on a convenience sample. RESULTS: In 268 women, human papillomavirus DNA was detected in 87 (32.5%) of them. Sexually transmitted diseases were detected in 30 (34.48%) of the 87 women with a positive or inconclusive result for human papillomavirus. Women with more than three pregnancies had a higher risk of human papillomavirus detection (p=0.004). CONCLUSION: The prevalence of human papillomavirus and other sexually transmitted diseases in encarcered women in Amazonas is 32.5 and 34.48%, respectively. Most women were single (60.4%) and reported having had more than 15 partners (90.8%).

Abstract Background Data on post-acute COVID-19 in autoimmune rheumatic diseases (ARD) are scarce, focusing on a single disease, with variable definitions of this condition and time of vaccination. The aim of this study was to evaluate the frequency and pattern of post-acute COVID-19 in vaccinated patients with ARD using established diagnosis criteria. Methods Retrospective evaluation of a prospective cohort of 108 ARD patients and 32 non-ARD controls, diagnosed with SARS-CoV-2 infection (RT-PCR/antigen test) after the third dose of the CoronaVac vaccine. Post-acute COVID-19 (≥ 4 weeks and > 12 weeks of SARS-CoV-2 symptoms) were registered according to the established international criteria. Results ARD patients and non-ARD controls, balanced for age and sex, had high and comparable frequencies of ≥ 4 weeks post-acute COVID-19 (58.3% vs. 53.1%, p = 0.6854) and > 12 weeks post-acute COVID-19 (39.8% vs. 46.9%, p = 0.5419). Regarding ≥ 4 weeks post-acute COVID-19, frequencies of ≥ 3 symptoms were similar in ARD and non-ARD controls (54% vs. 41.2%, p = 0.7886), and this was also similar in > 12 weeks post-acute COVID-19 (68.3% vs. 88.2%, p = 0.1322). Further analysis of the risk factors for ≥ 4 weeks post-acute COVID-19 in ARD patients revealed that age, sex, clinical severity of COVID-19, reinfection, and autoimmune diseases were not associated with this condition (p > 0.05). The clinical manifestations of post-acute COVID-19 were similar in both groups (p > 0.05), with fatigue and memory loss being the most frequent manifestations. Conclusion We provide novel data demonstrating that immune/inflammatory ARD disturbances after third dose vaccination do not seem to be a major determinant of post-acute COVID-19 since its pattern is very similar to that of the general population. Clinical Trials platform (NCT04754698).

ABSTRACT. The objective was to evaluate the quality of Japanese quail eggs stored at room temperature (26.8ºC) and under refrigeration (10.9ºC), for different storage periods (0; 5; 10; 15; 20; 25 and 30 days). A total of 196 quail eggs were assigned to different treatments in a factorial arrangement of 2 (temperatures) x 7 (storage periods), with 3 replications and 4 eggs per experimental unit. Data were subjected to regression analysis of parameters as a function of storage time at room temperature and under refrigeration. There was a reduction in egg weight, albumen weight and height, yolk height and egg yolk index with increasing storage period as a function of temperatures (p < 0.05). Eggs at room temperature showed a reduction in albumen index, while eggs under refrigeration showed a quadratic behavior (p < 0.05). Storage days promoted a quadratic response in albumen and yolk pH (p < 0.05) of eggs at room temperature. Eggs at room temperature floated from the 15th day of storage. When stored at room temperature, quail eggs show a sharp decrease in internal quality during storage for up to 30 days. Refrigerated storage is recommended.

ABSTRACT The aim of the study was to identify the 100 most cited articles on COVID-19 from Latin America and the Caribbean, published in Spanish. The records were obtained from the Web of Science. The following were examined: number of citations, authorship, geographic coverage, collaboration, journal and thematic categories. The 100 articles were published in 41 journals. The most cited journal was Salud Pública de México (10 articles; 75 citations). Mexico was the top performer (28 articles; 201 citations). The most cited authors were: C. Alpuche-Aranda and E. Lazcano-Ponce, affiliated with the most cited institution, the National Institute of Public Health of Mexico (n= 7). The main Web of Science category was Medicine, General & Internal (36 articles; 173 citations). Epidemiology was the most worked topic. There was no correlation between international collaboration and the highest number of citations (r= 0.15, p= 0.1). The study may help to recognize the visibility of the most cited research.

RESUMEN El objetivo del estudio fue identificar los 100 artículos más citados sobre COVID-19 procedentes de Latinoamérica y el Caribe, publicados en español. Los registros se obtuvieron de la Web of Science. Se examinó: número de citas, autoría, cobertura geográfica, colaboración, revista y categorías temáticas. Los 100 artículos se publicaron en 41 revistas. La revista más citada fue Salud Pública de México (10 artículos; 75 citas). México fue el máximo exponente (28 artículos; 201 citas). Los autores más citados fueron: C. Alpuche-Aranda y E. Lazcano-Ponce, afiliados a la institución más citada, el Instituto Nacional de Salud Pública de México (n= 7). La principal categoría de la Web of Science fue Medicine, General & Internal (36 artículos; 173 citas). Epidemiología fue el tema más trabajado. No hubo correlación entre la colaboración internacional y el mayor número de citas (r= 0,15, p= 0,1). El estudio puede ayudar a reconocer la visibilidad de las investigaciones más citadas.